Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects [see comments]

Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects.

Limited red blood cell (RBC) regeneration often prevents collection of sufficient blood from autologous donors. We studied the effects of subcutaneous recombinant erythropoietin (rEPO) in subjects making frequent blood donations. Six healthy iron-replete male subjects took rEPO (200 U/kg) subcutaneously daily, and donated blood (450 mL) twice a week for 3 weeks. During a control study, these su...

Erythropoietin, iron, and erythropoiesis.

Recent knowledge gained regarding the relationship between erythropoietin, iron, and erythropoiesis in patients with blood loss anemia, with or without recombinant human erythropoietin therapy, has implications for patient management. Under conditions of significant blood loss, erythropoietin therapy, or both, iron-restricted erythropoiesis is evident, even in the presence of storage iron and i...

Erythropoiesis, erythropoietin, and iron.

RED CELLS, IRON, AND ERYTHROPOIESIS Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin

1Département Médical, Ecole Nationale de Ski et d’Alpinisme, Chamonix, France; 2Department of Human Morphology and Biomedical Sciences Città Studi, University of Milano, Milano, Italy; 3Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy; 4Department of Sciences and Biomedical Technologies, University of Milano, Segrate, Italy; 5The Copenhagen Muscle Research C...

RED CELLS, IRON, AND ERYTHROPOIESIS Macrophages prevent human red blood cell reconstitution in immunodeficient mice

1Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China; 2Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 3Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, New Yo...